EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.38 | antithrombin III | inhibition is accelerated 300fold to 500fold by the addition of heparin, heparin alone has no effect | Bos taurus | |
3.4.21.38 | C1 esterase inhibitor | - |
Bos taurus | |
3.4.21.38 | diisopropyl phosphofluoridate | - |
Bos taurus | |
3.4.21.38 | Lima bean trypsin inhibitor | - |
Bos taurus | |
3.4.21.38 | phenyl methylsulfonyl fluoride | - |
Bos taurus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.4.21.38 | additional information | - |
amino acid sequence of the heavy chain, the active site region contains Asp-Ala-Cys-Gln-Gly-Asp-Ser-Gly-Gly sequence | Bos taurus |
3.4.21.38 | 28000 | - |
1 * 28000 + 1 * 46000, heavy chain and light chain held together by disulfide bonds | Bos taurus |
3.4.21.38 | 46000 | - |
1 * 28000 + 1 * 46000, heavy chain and light chain held together by disulfide bonds | Bos taurus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.38 | factor VII + H2O | Bos taurus | enzyme is involved in the blood coagulation cascade | ? | - |
? | |
3.4.21.38 | factor XI + H2O | Bos taurus | enzyme is involved in the blood coagulation cascade | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.38 | Bos taurus | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.4.21.38 | proteolytic modification | the conversion of factor XII to factor XIIa is due to the cleavage of a specific internal Arg-Val peptide bond | Bos taurus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.38 | benzoyl arginine ethyl ester + H2O | - |
Bos taurus | benzoyl-Arg + ethanol | - |
? | |
3.4.21.38 | factor VII + H2O | enzyme is involved in the blood coagulation cascade | Bos taurus | ? | - |
? | |
3.4.21.38 | factor VII + H2O | - |
Bos taurus | factor VIIa | - |
? | |
3.4.21.38 | factor XI + H2O | - |
Bos taurus | factor XIa + ? | - |
? | |
3.4.21.38 | factor XI + H2O | enzyme is involved in the blood coagulation cascade | Bos taurus | ? | - |
? | |
3.4.21.38 | N-benzoyl-L-Phe-L-Val-L-Arg-4-nitroanilide + H2O | - |
Bos taurus | ? | - |
? | |
3.4.21.38 | plasminogen proactivator + H2O | - |
Bos taurus | ? | - |
? | |
3.4.21.38 | prekallikrein + H2O | - |
Bos taurus | ? | - |
? | |
3.4.21.38 | tosyl arginine methyl ester + H2O | - |
Bos taurus | tosyl-Arg + methanol | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.4.21.38 | dimer | 1 * 28000 + 1 * 46000, heavy chain and light chain held together by disulfide bonds | Bos taurus |